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KMID : 0363319990200010057
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Journal of Korean Oriental Internal Medicine
1999 Volume.20 No. 1 p.57 ~ p.72
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Study on the Anti-inflammatory, Analgesic and Anticoagulative effects of Whalrakdan in the experimental animals
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Kang Seung-Bum
Park Jong-Woon
Kim Jong-Gil
Cho Nam-Su
Moon Byung-Soon
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Abstract
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This study was designed to elucidate the anti-inflammatory, cardiovascular, anti-thrombotic, and analgesic effect of Whalrakdan. The anti-inflammatory effects was measured by the method of carrageenin induced edema, protein leakage test using CMC-pouch, and the effect of Whalrakdan on the cardiovascular system was observed by the change of flow rate of Ringer solution in the vascular system in the ear of rabbit. and the contraction and dilatation of rat tail artery. Death rate, platelet aggregation, plasma coagulation activity, antithrombin activity was observed for the measurement of the anti-thrombotic effect of Whalrakdan, and the analgesic effect was measured by the acetic acid method and hot plate method. The result was as follows:
1. After 2 or 3hour of Whalrakdan administration, carrageenin induced edema and CMC-pouch protein leakage was significantly decreased.
2. The slight anagesic effect of Whalrakdan extract was confirmed by the observation of writhing syndrome, paw licking time, and escape time.
3. The droplet of Ringer solution increased according to the increase of concentration of Whalrakdan extract, and the vasoconstriction decreased dependantly to the concentration of Whalrakdan extract.
4. The anti-thrombotic effect of Whalrakdan was observed by the decrease of death rate, the inhibition of platelet aggregation, and the increase of anti-thrombin activity.
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KEYWORD
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whalrakdan, Anti-inflammatory, Analgesic, Anticoagulative
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